General Antibiotic Dosage Calculator (Renal Adjust)
Calculate antibiotic dosages with built-in adjustments for renal impairment. Select from top 50 primary care antibiotics.
About
Antibiotic stewardship requires not just selecting the right drug, but the right dose. A significant percentage of adverse drug events are caused by failure to adjust dosages for renal function. Accumulation of antibiotics like Ciprofloxacin or Vancomycin in patients with reduced Creatinine Clearance (CrCl) can lead to nephrotoxicity or neurotoxicity. This calculator serves as a rapid decision support tool for primary care.
The system integrates standard dosing regimens with a binary "Kidney Check" logic. While full nephrology consults use exact CrCl numbers, this tool allows a quick toggle for 'Impaired (<30 mL/min)' to instantly suggest the guideline-recommended dose reduction or interval extension, acting as a critical safety barrier in fast-paced clinical environments.
Formulas
The calculator applies a logic gate based on the renal flag.
IF Renal_Impairment == TRUE ∧ CrCl < 30 mL/min
Drugs with hepatic metabolism (e.g., Azithromycin) return NULL adjustment.
Reference Data
| Antibiotic | Standard Dose | Renal Adjust (CrCl < 30) | Common Usage |
|---|---|---|---|
| Amoxicillin | 500 mg q8h | 250-500 mg q12h | RTI, ENT |
| Ciprofloxacin | 500 mg q12h | 500 mg q24h | UTI |
| Levofloxacin | 500-750 mg q24h | 750 mg q48h | Pneumonia |
| Cephalexin | 500 mg q6h | 500 mg q12-24h | Skin/Soft Tissue |
| Nitrofurantoin | 100 mg q12h | CONTRAINDICATED | UTI (Lower) |
| Azithromycin | 500 mg Daily | No Adjustment | Atypical Pneumonia |
| Doxycycline | 100 mg q12h | No Adjustment | Tick-borne, Acne |
| Clindamycin | 300 mg q6-8h | No Adjustment | Dental, Skin |