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About

Standard GFR formulas like MDRD or CKD-EPI often fail in specific pediatric cohorts or patients with very low Body Mass Index (BMI), such as those with Cystic Fibrosis. In these unique clinical scenarios, the Duval formula provides a more accurate estimation of renal function by weighing height (length) more significantly against serum creatinine.

This calculator is specifically calibrated for these outlier populations. Unlike the Bedside Schwartz formula used for general pediatrics, the Duval algorithm offers an alternative validation point. It is critical to ensure the patient fits the demographic profile (typically 1-18 years or low-BMI adults) before relying on this output.

duval formula pediatric gfr kidney function cystic fibrosis low bmi

Formulas

The calculator implements the Duval algorithm logic commonly cited for specific pediatric validations:

eGFR = 0.73 × Height (cm)Scr (mg/dL)

Note: Some variations utilize 0.64 or age-dependent polynomials. This tool uses the standard 0.73 coefficient often associated with the Duval method for direct comparison against the Schwartz 0.413 constant.

Reference Data

FormulaTarget PopulationInput VariablesKey Constant
DuvalPediatrics / Low BMI / CFHeight, Creatinine, AgeDerived Coeff.
Bedside SchwartzGeneral PediatricsHeight, Creatinine0.413
CKD-EPIGeneral AdultsAge, Creatinine, GenderVariable

Frequently Asked Questions

Duval is often preferred in clinical research or specific sub-specialties like Cystic Fibrosis care, where muscle mass deficits skew creatinine generation differently than in the general pediatric population.
Generally, no. For adults over 18, CKD-EPI is the standard. However, Duval may be considered experimentally in adults with severe malnutrition or extremely low BMI where standard surface-area corrections fail.