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About

Chronic Kidney Disease (CKD) prognosis is not determined by GFR alone. The 2012 KDIGO (Kidney Disease: Improving Global Outcomes) guidelines established a two-dimensional classification system that includes Albuminuria-the presence of protein in urine. This tool places patient data onto the KDIGO Heatmap to determine the risk of progression to renal failure and cardiovascular mortality. By combining the GFR Stage (G1-G5) with the Albuminuria Stage (A1-A3), clinicians can identify patients who need more intensive monitoring (e.g., 4 times per year) versus those who are stable.

kdigo ckd risk albuminuria kidney failure medical calculator

Formulas

Risk is determined by a lookup matrix M(G, A).

Risk = KDIGO(GFR, ACR)

Green: Low Risk (Monitor 1x/yr)
Yellow: Moderate Risk (Monitor 1x/yr)
Orange: High Risk (Monitor 2x/yr)
Red: Very High Risk (Monitor 3-4x/yr)

Reference Data

Albuminuria CategoryACR (mg/g)ACR (mg/mmol)Description
A1< 30< 3Normal to mildly increased
A230 - 3003 - 30Moderately increased
A3> 300> 30Severely increased

Frequently Asked Questions

Albumin is a protein typically found in blood. Healthy kidneys prevent it from leaking into urine. Its presence in urine (Albuminuria) is an early sign of kidney damage, often appearing before GFR levels drop.
ACR stands for Albumin-to-Creatinine Ratio. It is the preferred method for detecting protein loss because it corrects for urine concentration variations, unlike a simple dipstick test.
This classification indicates a significant probability of progressing to End-Stage Renal Disease (ESRD) requiring dialysis, as well as an increased risk of acute kidney injury and cardiovascular events.