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Carboplatin Dosage Calculator (Calvert)

Calculate total Carboplatin dose using the Calvert Formula based on target AUC and GFR (estimated via Cockcroft-Gault).

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About

Carboplatin dosing is unique in oncology because it is calculated based on kidney function and a target Area Under the Curve (AUC) rather than Body Surface Area (BSA). The Calvert Formula allows for a predictable drug exposure, reducing the risk of severe thrombocytopenia while ensuring efficacy.

This calculator performs a two-step verification. First, it estimates the Glomerular Filtration Rate (GFR) using the Cockcroft-Gault equation based on Serum Creatinine, age, weight, and gender. Second, it applies the Calvert logic. Note that GFR is typically capped (e.g., at 125 mL/min) in these calculations to prevent potential overdose in patients with hyperfiltration. This tool is intended for clinical verification.

oncology chemotherapy calvert formula gfr carboplatin

Formulas

Step 1: Estimate GFR (Cockcroft-Gault)

GFR = (140 − Age) × Weight72 × SCr × (0.85 if Female)

Step 2: Calvert Formula

Dose mg = AUC × (GFR + 25)

Reference Data

Protocol / IntentTypical Target AUCFrequency
Curative (Single Agent)5 - 7Every 3-4 Weeks
Combination Chemotherapy4 - 6Every 3-4 Weeks
Weekly Protocol2Weekly
High Dose (Transplant)15+Specific Regimens

Frequently Asked Questions

The original Calvert formula was validated using GFR measured by 51Cr-EDTA. In the absence of measured GFR, the Cockcroft-Gault equation was the standard proxy used during the drug's development. While CKD-EPI is more accurate for staging kidney disease, most oncology guidelines still recommend Cockcroft-Gault for Carboplatin dosing to maintain consistency with historical efficacy data.
Yes. GFR is often capped at 125 mL/min to prevent overdosing in patients with low creatinine levels (which falsely elevates estimated GFR). Consequently, the maximum dose for an AUC of 6 is typically 6 x (125 + 25) = 900 mg.
In elderly or cachectic patients with very low muscle mass, serum creatinine may be artificially low (< 0.7 mg/dL), leading to an overestimated GFR. Some protocols recommend rounding SCr up to a minimum of 0.7 or 0.8 mg/dL to avoid toxicity.